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Immunogenicity of a 23-valent pneumococcal polysaccharide vaccine among Mexican children
Sara Elva Espinosa-Padilla1, Chiharu Murata, Sergio Estrada-Parra
1Immunodeficiency Research Unit, National Institute of Pediatrics, Mexico City, Mexico.
Background And Aims:
Streptococcus pneumoniae infection continues to be a major source of morbidity and mortality in children in Mexico. The aim of this study was to evaluate the immune response to six serotypes in children <5 years of age after immunization with a 23-valent pneumococcal polysaccharide vaccine.
Methods:
A prospective study was conducted among children aged from 18 months to 4 years. Pre- and postvaccination titers for the serotypes selected in this project demonstrate a substantial response among all age groups.
Results:
We identified mild adverse events in 62% of the participants in this study. No serious adverse events were reported during the study.
Conclusions:
Pneumococcal polysaccharide vaccine produced adequate immunogenicity in all age groups evaluated.
