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[Urinary FDP D-dimer and E fragments in renal transplantation]
T Akiyama1, M Ikegami, M Imanishi
1Department of Urology, Kinki University School of Medicine.
Nihon Hinyokika Gakkai Zasshi. the Japanese Journal of Urology
|November 1, 1990
Summary
Urinary E fragments are better indicators of renal transplant rejection than whole urinary FDP. The D-dimer/FDP ratio may predict rejection reversibility and guide treatment with fibrinolytic therapy.
Area of Science:
- Nephrology
- Transplantation immunology
- Clinical chemistry
Context:
- Renal transplant rejection remains a significant clinical challenge.
- Accurate early detection and prognosis prediction are crucial for graft survival.
- Current diagnostic markers for rejection have limitations.
Purpose:
- To evaluate urinary D-dimer and E fragments as indicators of renal transplant rejection.
- To assess the utility of the urinary D-dimer/FDP ratio in predicting rejection reversibility and graft prognosis.
Summary:
- Urinary E fragments showed higher sensitivity for detecting acute and chronic rejection compared to whole urinary FDP.
- Increased urinary D-dimer suggests glomerular intravascular coagulation during rejection.
- The urinary D-dimer/FDP ratio correlated with graft function, decreasing during rejection crises and increasing during recovery.
Impact:
- Urinary FDP-E fragments may serve as a more sensitive biomarker for renal transplant rejection.
- The D-dimer/FDP ratio shows potential for predicting rejection reversibility and allograft prognosis.
- Findings support exploring combined fibrinolytic/thrombolytic and immunosuppressive therapy for enhanced treatment outcomes.