[Bleeding in hemophilia as a function of meteorologic changes and the effect of tissue hormones]

Hemophilia is a hereditary coagulopathy which has the characteristic of bleeding into various tissues, particularly joints and muscles, bearing the risk of early invalidity. A lot of bleedings in children with hemophilia occur without any recognizable trauma, spontaneously and during the night. By comparing the frequency of bleeding in hemophiliacs with meteorological phenomena, and by the one year material revision of the Hematology Department of the Institute for Child Care in Novi Sad (Yugoslavia) as well as the simultaneous recording of barometric pressure, it was found that the increase of atmospheric pressure was strongly associated with spontaneous bleedings in hemophiliacs. It is accompanied with a rise in negative air ions that when inhaled interact with platelets and decrease blood serotonin, thus blocking its vasoconstrictor effect and precipitating bleeding. Antiserotonin activity drugs can have a similar influence.