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A new resveratrol trimer derivative from Gnetum brunonianum
Chun-Suo Yao1, Mao Lin, Qing-Yun Yang
1State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Abstract:
A new resveratrol trimer derivative, named as gnetubrunol A (1), together with five known stilbene derivatives, shegansu B (2), resveratrol (3), isorhapontigenin (4), gnetifolin E (5), and isorhapontigenin-11-O-β-d-glucopyranoside (6) were isolated from the lianas of Gnetum brunonianum Griff. Their structures were elucidated on the basis of spectral analysis (UV, IR, MS, (1)H NMR, (13)C NMR, and 2D NMR). The anti-inflammatory activities of 1, 5, and 6 have also been assayed.