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Related Concept Videos

Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations01:19

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...
Pericarditis I: Introduction01:22

Pericarditis I: Introduction

Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...

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Related Experiment Video

Updated: May 19, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Relapsing polychondritis on PET/CT.

Huaifu Deng1, Ping Chen, Lijuan Wang

  • 1PET/CT Center, Department of Nuclear Medicine, The First Affiliated Hospital, Guangzhou Medical College, Guangzhou, China.

Clinical Nuclear Medicine
|August 10, 2012
PubMed
Summary
This summary is machine-generated.

Relapsing polychondritis is a rare condition causing cartilage inflammation. Positron emission tomography/CT effectively detects multisystemic cartilaginous abnormalities indicative of this disease.

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Area of Science:

  • Rheumatology
  • Radiology
  • Medical Imaging

Background:

  • Relapsing polychondritis (RP) is a rare multisystemic autoimmune disease.
  • Characterized by recurrent inflammation and destruction of cartilaginous structures.
  • Diagnosis can be challenging due to its rarity and varied presentation.

Observation:

  • A 37-year-old male presented with progressive respiratory distress.
  • Chest CT revealed airway wall thickening and increased attenuation.
  • Positron emission tomography/CT (PET/CT) demonstrated widespread cartilaginous abnormalities.

Findings:

  • Increased fluorine-18 deoxyglucose (FDG) uptake was observed in nasal, laryngeal, tracheobronchial, and rib cartilages.
  • PET/CT identified multisystemic involvement characteristic of relapsing polychondritis.
  • FDG uptake correlated with cartilaginous abnormalities in RP.

Implications:

  • PET/CT is a valuable diagnostic tool for relapsing polychondritis.
  • This imaging modality can reveal subclinical cartilaginous involvement.
  • Early diagnosis through advanced imaging can potentially improve patient outcomes.