Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
What is the Skeletal System?01:02

What is the Skeletal System?

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implications of GLP-1 RA Therapy on Skeletal Health and Orthopedics: A Commentary.

HSS journal : the musculoskeletal journal of Hospital for Special Surgery·2026
Same author

Knowledge, skills, and attitudinal gaps in fibrodysplasia ossificans progressiva diagnosis and management in the United States.

JBMR plus·2026
Same author

Bone Health in Patients With Adrenal Adenomas and Hypercortisolism: A Multicenter Cross-Sectional Study.

Clinical endocrinology·2025
Same author

Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition.

Experimental hematology & oncology·2025
Same author

Bone anabolic therapy in breast cancer: is there a role for parathyroid hormone or parathyroid hormone-related protein?

JBMR plus·2025
Same author

Gallium-68-DOTATATE PET/CT for phosphaturic mesenchymal tumor localization in suspected tumor-induced osteomalacia.

JBMR plus·2025
Same journal

Navigating Adrenal Disease: A Comprehensive, Practical Guide for the Clinician.

Endocrinology and metabolism clinics of North America·2026
Same journal

Adrenal Disorders in Pregnancy.

Endocrinology and metabolism clinics of North America·2026
Same journal

Diagnosis and Management of Adrenocortical Carcinoma.

Endocrinology and metabolism clinics of North America·2026
Same journal

Pheochromocytomas and Paragangliomas.

Endocrinology and metabolism clinics of North America·2026
Same journal

Hereditary Conditions Associated with Adrenocortical Carcinoma, Pheochromocytoma, and Other Adrenal Tumors: Genetic Testing and Management Recommendations.

Endocrinology and metabolism clinics of North America·2026
Same journal

Primary Bilateral Macronodular Adrenal Hyperplasia.

Endocrinology and metabolism clinics of North America·2026
See all related articles

Related Experiment Video

Updated: May 19, 2026

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model
06:59

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model

Published on: September 8, 2023

Male osteoporosis.

Matthew T Drake1, Sundeep Khosla

  • 1Department of Medicine, Division of Endocrinology, College of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. drake.matthew@mayo.edu

Endocrinology and Metabolism Clinics of North America
|August 11, 2012
PubMed
Summary
This summary is machine-generated.

Osteoporosis poses a significant health risk for aging men, with hip fractures leading to substantial mortality. Declining estradiol levels contribute to age-related bone loss, necessitating medical and supportive interventions for at-risk individuals.

Related Experiment Videos

Last Updated: May 19, 2026

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model
06:59

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model

Published on: September 8, 2023

Area of Science:

  • Gerontology
  • Endocrinology
  • Orthopedics

Background:

  • Osteoporosis is a growing health concern for the aging male population.
  • Significant morbidity and mortality are associated with osteoporosis-related fractures, especially hip fractures.
  • Cortical bone loss in men typically begins in midlife, unlike trabecular bone loss which starts earlier.

Purpose of the Study:

  • To highlight osteoporosis as a major health threat in aging men.
  • To emphasize the role of declining bioavailable estradiol in male age-associated bone loss.
  • To underscore the importance of interventions for men at increased fracture risk.

Main Methods:

  • Review of current understanding of osteoporosis in aging men.
  • Analysis of the role of hormonal changes, specifically estradiol, in bone density.
  • Evaluation of current treatment strategies for male osteoporosis.

Main Results:

  • Osteoporosis is a significant cause of morbidity and mortality in aging men.
  • Decreased levels of bioavailable estradiol are a key factor in age-related bone loss in men.
  • Pharmacologic and supportive care are crucial for managing fracture risk.

Conclusions:

  • Osteoporosis is a critical health issue for aging men, with substantial consequences.
  • Estradiol decline is integral to bone loss in aging males.
  • Comprehensive management including pharmacologic and supportive care is essential for reducing fracture risk.