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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
Osmoregulation in Fishes02:32

Osmoregulation in Fishes

When cells are placed in a hypotonic (low-salt) fluid, they can swell and burst. Meanwhile, cells in a hypertonic solution—with a higher salt concentration—can shrivel and die. How do fish cells avoid these gruesome fates in hypotonic freshwater or hypertonic seawater environments?

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Related Experiment Video

Updated: May 19, 2026

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

Circadian clocks: lessons from fish.

M Laura Idda1, Cristiano Bertolucci2, Daniela Vallone1

  • 1Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Hermann-von-Helmholtz-Platz, Eggenstein-Leopoldshafen, Germany.

Progress in Brain Research
|August 11, 2012
PubMed
Summary
This summary is machine-generated.

Fish models reveal circadian clock flexibility and evolution. Studies highlight light input, pineal organ function, and adaptation in blind cavefish, advancing vertebrate clock biology research.

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Related Experiment Videos

Last Updated: May 19, 2026

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
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Published on: September 27, 2012

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Published on: January 19, 2018

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Area of Science:

  • * Chronobiology and molecular biology.
  • * Comparative physiology and evolutionary biology.

Background:

  • * Significant advancements in understanding vertebrate circadian timing systems over the last decade.
  • * Progress driven by mouse genetics and conserved clock mechanisms across species.
  • * Initial focus on zebrafish as a primary genetic model for clock gene discovery.

Purpose of the Study:

  • * To explore the utility of fish as complementary models in circadian biology.
  • * To investigate the plasticity and specific functions of the vertebrate circadian clock.
  • * To examine the role of light input and the pineal organ in fish circadian regulation.

Main Methods:

  • * Comparative analysis of circadian clock mechanisms in various fish species.
  • * Observation of behavioral shifts (diurnal to nocturnal activity).
  • * Studies on light input pathways and pineal organ development and function.
  • * Investigation of blind cavefish to understand clock evolution under extreme conditions.

Main Results:

  • * Fish models demonstrate significant flexibility in circadian clock function, including activity phase shifts.
  • * Detailed understanding of light input pathways and the central pacemaker role of the pineal organ in fish.
  • * Blind cavefish provide unique insights into circadian clock evolution and adaptation.

Conclusions:

  • * Fish are valuable complementary models for studying diverse aspects of circadian clock biology.
  • * The fish circadian system exhibits notable functional plasticity and offers insights into evolutionary adaptations.
  • * Research in fish enhances our comprehension of vertebrate circadian organization, light signaling, and evolutionary trajectories.