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Updated: May 19, 2026
10:19
Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
Published on: August 9, 2012
Bulking agents: a urogynecology perspective
1Department of Obstetrics and Gynecology, The Christ Hospital/University of Cincinnati, Cincinnati, OH 45267, USA.
The Urologic Clinics of North America
|August 11, 2012
Summary
Injectable bulking agents improve urethral coaptation for women with stress incontinence. Collagen became the gold standard due to its proven safety and efficacy in treating urinary leakage.
Area of Science:
- Urology
- Biomaterials
Background:
- Injectable bulking agents are used to treat stress urinary incontinence by improving urethral coaptation.
- Historically, materials like sodium morrhuate, paraffin, and sclerosing agents were employed.
- Collagen and autologous fat emerged as effective options, with collagen establishing itself as the gold standard.
Purpose of the Study:
- To provide a historical overview of injectable bulking agents for stress incontinence.
- To highlight the evolution of materials used for urethral augmentation.
- To discuss the development and comparative efficacy of different injectable agents.
Main Methods:
- Literature review of historical and contemporary injectable bulking agents.
- Analysis of materials used for urethral augmentation and their outcomes.
- Examination of safety and efficacy data for various agents.
Main Results:
- Early agents like sodium morrhuate and paraffin had limited success.
- Sclerosing agents aimed for permanent urethral scarring.
- Collagen demonstrated proven safety and efficacy, becoming the gold standard, while other agents have varying success rates and complications.
Conclusions:
- Injectable bulking agents have evolved significantly over decades.
- Collagen represents a well-established and safe option for stress incontinence treatment.
- Ongoing development yields new agents with diverse clinical profiles.
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