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Updated: May 19, 2026
10:03
Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
Published on: August 1, 2017
Osteohematopoietic stem cell niches in bone marrow.
Samiksha Wasnik1, Abhilasha Tiwari, Mark A Kirkland
1CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
International Review of Cell and Molecular Biology
|August 11, 2012
Summary
The bone marrow
Area of Science:
- Stem cell biology
- Hematopoiesis
- Regenerative Medicine
Background:
- Adult mammals mature blood and bone cells in the bone marrow.
- Stem cell niches are microenvironments that support specific progenitor and stem cell types.
- The osteohematopoietic niche is well-studied but much remains unknown.
Purpose of the Study:
- To review current knowledge on bone marrow stem cell niches.
- To explore the relationship between hematopoietic stem cell biology and niche properties.
- To suggest applications of hematopoietic progenitors in regenerative medicine.
Main Methods:
- Review of current scientific literature on bone marrow niches.
- Analysis of the properties of the osteohematopoietic niche.
- Discussion of the potential of hematopoietic progenitors in regenerative medicine.
Main Results:
- The bone marrow contains diverse stem cell niches regulating cell behavior.
- The osteohematopoietic niche serves as a model for adult stem cell differentiation.
- Understanding these niches is crucial for safe and effective regenerative medicine.
Conclusions:
- Further research into stem cell niches is needed.
- Improved understanding can advance the use of hematopoietic progenitors in therapy.
- Stem cell niches play a vital role in maintaining tissue homeostasis and regeneration.
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