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Six-year retrospective analysis of colonic perforation in neonates and infants: single centre experience

Sunita Singh1, Jiledar Rawat, Ashish Wakhlu

  • 1Department of Pediatric Surgery, CSM Medical University, Lucknow, Uttar Pradesh, India.

African Journal of Paediatric Surgery : AJPS
|August 11, 2012
PubMed

Insights

Hirschsprung's disease (HD) is a leading cause of colonic perforation in infants. Early diagnosis via colonic biopsy is crucial for neonates presenting with perforation, as it can be the first sign of HD.

Area of Science:

  • Pediatric Surgery
  • Neonatalogy
  • Gastroenterology

Background:

  • Colonic perforation (CP) is a serious condition in neonates and infants.
  • Tertiary referral centers in developing countries manage a significant number of these cases.

Purpose of the Study:

  • To analyze the causes of colonic perforation in neonates and infants.
  • To investigate the association between Hirschsprung's disease and colonic perforation.

Main Methods:

  • Retrospective analysis of 60 cases of colonic perforation.
  • Data collected from May 2005 to May 2011.

Main Results:

  • Hirschsprung's disease (HD) was the most common cause of CP, accounting for 78.33% of cases.
  • The mid-transverse colon was the most frequent site of perforation in HD patients.
  • 22.38% of patients with histopathologically proven HD presented with CP.

Conclusions:

  • A high incidence of primary HD-associated colonic perforation was observed.
  • Colonic perforation can be the initial presentation of Hirschsprung's disease.
  • Recommend colonic biopsy for neonates with primary colonic perforation to exclude HD.
Abstract

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