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Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
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High-throughput Screening for Protein-based Inheritance in S. cerevisiae
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Published on: August 8, 2017

Prions in yeast.

Susan W Liebman1, Yury O Chernoff

  • 1Department of Biochemistry and Molecular Biology, University of Nevada, Reno, Nevada 89557, USA. suel@uic.edu

Genetics
|August 11, 2012
PubMed
Summary
This summary is machine-generated.

Yeast prions, infectious proteins, demonstrate heritable traits and are typically amyloid aggregates. Recent discoveries highlight yeast

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Budding Yeast Protein Extraction and Purification for the Study of Function, Interactions, and Post-translational Modifications

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Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Prions, infectious self-propagating protein isoforms, were first proposed to explain mammalian diseases.
  • The "protein only" model of prion transmission was initially validated using yeast prions.
  • Known prions typically form ordered cross-β aggregates, known as amyloids.

Purpose of the Study:

  • To review the significant advancements in understanding yeast prions.
  • To summarize the current knowledge on prion propagation, structure, formation, transmission, and biological roles in yeast.

Main Methods:

  • Review of existing scientific literature on yeast prions.
  • Synthesis of findings related to prion biology in yeast.

Main Results:

  • A recent surge in the identification of new yeast prions.
  • Yeast serves as a leading model for studying prion propagation control, structure, de novo formation, transmission specificity, and biological functions.

Conclusions:

  • Yeast prions are crucial for understanding the fundamental mechanisms of protein-based inheritance.
  • Ongoing research in yeast continues to expand our knowledge of prion biology and its implications.