[Age-related dynamics of structure changes in the 17th cortical area of children with perinatal affection of the
Insights
Children with perinatal brain affections show reduced neuron size and density in the visual cortex. Glial cell density, including GFAP-positive astroglia, was higher, indicating potential destructive and compensatory brain changes.
Area of Science:
- Neuroscience
- Developmental Biology
- Pathology
Abstract:
Brain autopsy of children standing afterperinatal affection of the nervous system and healthy children without any neurological disorders (a control group) has been studied by computers morphometric methods. The age-related dynamics of structure parameters in the 17th cortical area was investigated. Correlation between increasing of cortical lamina's diameters and age of children with perinatal affection of the brain wasn't revealed. The width of IVand V cortical layers, size of neurons and their density in the cortex of children with perinatal pathology were significantly fewer than in the control group. However the density of glia including GFAP-positive astroglia in the children with prenatal pathology was higher to compare with the control group. We suggest that detected disorders are signs of nonspecific structure-functional changes in the visual cortex and follows destructive and compensatory restorative reactions.
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