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[Lethal midline granuloma as a result of months-long immunosuppressive therapy. A case report]
1Universitäts-Hals-Nasen-Ohren-Klinik Heidelberg.
A case of lethal midline granuloma is reported, which resulted from immunosuppressive therapy with corticoids over months because of pulmonary fibrosis. An autoimmune disease according to a cell mediated immune reaction (type IV--classification of Coombs and Gell) is discussed. Wegener's granulomatosis and a T-cell lymphoma were excluded. Continuation of this lymphoproliferative disease would eventually have resulted in a T-cell lymphoma.
A case of lethal midline granuloma is reported, which resulted from immunosuppressive therapy with corticoids over months because of pulmonary fibrosis. An autoimmune disease according to a cell mediated immune reaction (type IV--classification of Coombs and Gell) is discussed. Wegener's granulomatosis and a T-cell lymphoma were excluded. Continuation of this lymphoproliferative disease would eventually have resulted in a T-cell lymphoma.