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Risk factors for pseudogout in the general population
Young Hee Rho1, Yanyan Zhu, Yuqing Zhang
1Section of Rheumatology and the Clinical Epidemiology Unit, Boston University School of Medicine, 650 Albany Street, Suite 200, Boston, MA 02118, USA.
Rheumatology (Oxford, England)
|August 14, 2012
Summary
Pseudogout risk is linked to hyperparathyroidism, osteoarthritis, and loop diuretics. Rheumatoid arthritis and thiazide diuretics were not associated, but chronic renal failure was. Avoiding loop diuretics may help prevent recurrent pseudogout.
Area of Science:
- Rheumatology
- Epidemiology
- General Practice
Background:
- Pseudogout (calcium pyrophosphate deposition disease) risk factors are not fully understood.
- Previous studies suggest associations with chondrocalcinosis risk factors, but general population data is limited.
Purpose of the Study:
- To investigate the association between known chondrocalcinosis and gout risk factors and the incidence of pseudogout in the general population.
- To identify specific risk factors for pseudogout.
Main Methods:
- A UK general practice database (The Health Improvement Network) was used for a nested case-control study.
- Incident pseudogout cases (1986-2007) were identified and matched with up to 10 controls.
- Conditional logistic regression analyzed associations with osteoarthritis, rheumatoid arthritis, hyperparathyroidism, and diuretics.
Main Results:
- 795 pseudogout cases and 7770 controls were analyzed.
- Pseudogout risk was associated with hyperparathyroidism (OR 4.87), osteoarthritis (OR 2.91), and loop diuretic use (OR 1.35).
- Chronic renal failure showed an association (OR 2.29), while rheumatoid arthritis and thiazide diuretics did not.
Conclusions:
- Most chondrocalcinosis associations are replicable for pseudogout risk in the general population.
- Notable differences exist, including RA and thiazide diuretics, underscoring the need for pseudogout-specific research.
- Avoiding loop diuretics might benefit individuals experiencing recurrent pseudogout.
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