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Updated: May 19, 2026

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
Published on: August 30, 2020
Magnesium sulphate for aneurysmal subarachnoid hemorrhage: why, how, and current controversy
George Kwok Chu Wong1, Wai Sang Poon
1The Chinese University of Hong Kong, Shatin, Hong Kong, China. georgewong@surgery.cuhk.edu.hk
Abstract:
The neuroprotective effect of magnesium sulphate infusion has been confirmed in experimental models. Pilot clinical trials using magnesium sulphate in patients with acute aneurysmal subarachnoid hemorrhage (SAH) have reported a trend toward a reduction in clinical deterioration due to delayed cerebral ischemia (DCI) and an improvement in clinical outcomes. However, our recent multicenter trials and systemic review failed to confirm benefit in neurological outcome. In post hoc analysis, data also did not support that a higher dose of magnesium sulphate infusion might improve clinical outcome. We here review the current literature, highlight these discrepancies, and explore alternatives.
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