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Correlation of recognition visual acuity with posterior retinal structure in advanced retinopathy of prematurity

David K Wallace, Don L Bremer, William V Good

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |August 16, 2012
    PubMed

    Insights

    Visual acuity outcomes in infants with retinopathy of prematurity generally align with retinal structure at age 6. However, poor vision with normal retinas may indicate optic atrophy or cortical visual impairment.

    Area of Science:

    • Ophthalmology
    • Pediatric Medicine
    • Retinal Imaging

    Background:

    • Retinopathy of prematurity (ROP) is a leading cause of childhood blindness.
    • Assessing long-term visual outcomes in ROP is crucial for understanding disease progression and treatment efficacy.

    Purpose of the Study:

    • To compare visual acuity outcomes with retinal structural outcomes at 6 years in infants randomized in the Early Treatment for Retinopathy of Prematurity study.
    • To investigate the correlation between functional vision and retinal anatomy in infants with a history of severe ROP.

    Main Methods:

    • A cohort of 606 eyes from the Early Treatment for ROP study underwent visual acuity and retinal structural assessments at age 6.
    • Visual acuity was measured by masked testers, and retinal examinations were performed by certified ophthalmologists.

    Main Results:

    • Concordant functional and structural outcomes were observed in 76.2% of eyes.
    • Discordant outcomes occurred in 15.2% of eyes, with 86 eyes showing unfavorable vision despite favorable retinal structure.
    • Optic atrophy and less severe retinal abnormalities accounted for discrepancies in eyes with poor vision and normal retinas.

    Conclusions:

    • Posterior pole appearance correlates well with visual acuity in 6-year-old infants with a history of advanced ROP.
    • In cases of poor vision with normal retinal structure, clinicians should consider optic atrophy and cortical visual impairment as potential contributing factors.

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