Inflammatory markers of gallstones disease in menopausal women

Among the factors contributing to the gallstones formation an important role belongs to the inflammation. The goal of our research - determination alterations of the redox balance and cytokines (IL-1α, IL-6, IL-8, TNF-α) content in the blood postmenopausal women with gallstone disease. 58 menopausal women with gallstone disease, who had been admitted to the LTD "1-st Clinic" (Tbilisi, Georgia) during 2009-2011 were studied. Gallstone disease was proved by Ultrasonography method. The control group consisted of 25 menopause aged women without gallstone disease. The Local Ethics Committee approved the protocol, and informed consent was obtained from all participants or their surrogates. Patients was conducted for blood redox status (EPR signals of superoxide (O2-) and lipoperoxide (LOO.) radicals) and citokins (IL-1α, IL-6, IL-8, TNF-α) content. It was revealed increase production of oxygen and lipoperoxide free radicals, macrophage inflammatory cytokines (IL-6, IL-1α, TNF-α) in blood of menopausal women with gallstone disease. It was concluded that macrophages play a dominant role in the inflammatory and oxidative response during gallbladder stones disease in postmenopausal women.