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Methylenetetrahydrofolate reductase C677T polymorphism and cervical cancer risk: a meta-analysis
1Department of Obstetrics and Gynecology, General Hospital of Tianjin Medical University, Tianjin, China. guolntj@yahoo.cn
Background:
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate, and the role of MTHFR C677T polymorphism in cervical carcinogenesis is still controversial.
Method:
We performed a meta-analysis of all relevant case-control studies that examined any association between the C677T polymorphism and cervical cancer risk. We estimated summary odds ratios (ORs) with their confidence intervals (CIs) to assess links.
Results:
Finally, 10 studies with a total of 2113 cervical cancer cases and 2804 controls were included. Results from this meta-analysis showed that significantly elevated cervical cancer risk was associated with the MTHFR T allele in the Asian population under conditions of two genetic comparison models (for TT vs. CC, OR=1.37, 95%CI 1.00-1.87, P=0.050; for TT vs. TC+CC: OR=1.34, 95%CI 1.01-1.77, P=0.039). However, there was no obvious association between the MTHFR C677T polymorphism and cervical cancer risk in the other populations.
Conclusion:
The MTHFR C677T polymorphism is associated with cervical cancer risk in Asians, while any possible link in the Caucasian population needs further studies.
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Single Nucleotide Polymorphisms-SNPs
