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E-cadherin expression as a prognostic factor in transitional cell carcinoma of the bladder after transurethral
Mohammad Hatef Khorrami1, Mazaher Hadi, Mohammad Reza Gharaati
1Department of Urology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Purpose:
To analyze the role of negative versus positive immunoexpression of E-cadherin in recurrence rate of low-grade bladder tumors.
Materials And Methods:
A total of 180 patients with unifocal, superficial, low-grade, papillary transitional cell carcinoma of the bladder were included in this study. The E-cadherin expression was evaluated using E-cadherin antibody. The patients were followed up for 36 months. Thereafter, recurrence rate of the tumor was compared between E-cadherin positive and negative groups.
Results:
Of 180 low-grade carcinomas, E-cadherin immunoexpression was negative in 101 (56%) and positive in 79 (44%) patients. The recurrence rate in negative and positive groups was 65.6% and 37.9%, respectively. Negative in comparison with positive E-cadherin expression was associated with more disease recurrence (P = .045).
Conclusion:
There is an association between decreased E-Cadherin immunoexpression and tumor recurrence in low-grade and non-muscle invasive transitional cell carcinoma of the bladder.
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