Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Overview of Cell Death01:30

Overview of Cell Death

Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Autophagic Cell Death01:18

Autophagic Cell Death

Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and pro-apoptotic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ERBB4 deficiency promotes atrial myopathy underlying the atrial fibrillation substrate.

medRxiv : the preprint server for health sciences·2026
Same author

The Utility of Higher Pulsed Field Ablation Applications for Atrial Fibrillation Ablation.

Journal of cardiovascular electrophysiology·2026
Same author

Vein of Marshall Ethanol Infusion for Recurrent Atrial Fibrillation Patients Presenting for Redo Ablation: A Systematic Review and Meta-Analysis.

Journal of cardiovascular electrophysiology·2026
Same author

The utility of high-frequency jet ventilation in pulsed field ablation for atrial fibrillation.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing·2026
Same author

Three-dimensional visualization of arrhythmogenic substrate in mouse hearts using panoramic optical mapping and micro-computed tomography.

Nature cardiovascular research·2026
Same author

A reduced TBX5-dependent gene regulatory network links atrial fibrillation and heart failure.

Nature cardiovascular research·2026
Same journal

The Biology of Malaria Parasite Liver Infection.

Cold Spring Harbor perspectives in medicine·2026
Same journal

The Interaction between Diabetes Mellitus and Tuberculosis: Epidemiology, Screening, and Clinical Management.

Cold Spring Harbor perspectives in medicine·2026
Same journal

New Malaria Prevention Modalities: Long-Acting Interventions Beyond Vaccines.

Cold Spring Harbor perspectives in medicine·2026
Same journal

From Parasite to Pill: Harnessing Biology for Breakthroughs in Antimalarial Drug Discovery.

Cold Spring Harbor perspectives in medicine·2026
Same journal

Malaria Parasite Genomics: Decentralization, Diversification, and Development Goals.

Cold Spring Harbor perspectives in medicine·2026
Same journal

Tuberculosis Infection: Diagnosis and Management.

Cold Spring Harbor perspectives in medicine·2026
See all related articles

Related Experiment Video

Updated: May 19, 2026

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies
12:13

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies

Published on: July 11, 2019

Programmed cell death in Parkinson's disease.

Katerina Venderova1, David S Park

  • 1University of the Pacific, Thomas J. Long School of Pharmacy, Department of Physiology and Pharmacology, Stockton, CA 95211, USA. kvenderova@pacific.edu

Cold Spring Harbor Perspectives in Medicine
|August 22, 2012
PubMed
Summary
This summary is machine-generated.

This review details programmed cell death pathways in Parkinson's disease (PD), highlighting apoptosis, autophagic cell death, and programmed necrosis. Understanding these mechanisms is crucial for PD research and potential therapies.

More Related Videos

Phenotypic Profiling of Human Stem Cell-Derived Midbrain Dopaminergic Neurons
09:21

Phenotypic Profiling of Human Stem Cell-Derived Midbrain Dopaminergic Neurons

Published on: July 7, 2023

Related Experiment Videos

Last Updated: May 19, 2026

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies
12:13

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies

Published on: July 11, 2019

Phenotypic Profiling of Human Stem Cell-Derived Midbrain Dopaminergic Neurons
09:21

Phenotypic Profiling of Human Stem Cell-Derived Midbrain Dopaminergic Neurons

Published on: July 7, 2023

Area of Science:

  • Neuroscience
  • Cell Biology
  • Pathology

Background:

  • Parkinson's disease (PD) involves progressive dopaminergic neuron loss.
  • Programmed cell death (PCD) is the primary mechanism behind this neuronal loss.
  • Historically, apoptosis was the main focus, but other PCD types are now recognized in PD.

Purpose of the Study:

  • To provide an updated review of major programmed cell death pathways implicated in Parkinson's disease.
  • To explore the roles of apoptosis, autophagic cell death, and programmed necrosis in PD pathogenesis.
  • To consolidate evidence from various PD models and genetic factors.

Main Methods:

  • Review of existing literature on programmed cell death pathways in PD.
  • Analysis of evidence from postmortem Parkinson's disease studies.
  • Examination of data from toxin-induced models (MPTP, 6-OHDA, rotenone) and genetic PD models (α-synuclein, LRRK2, Parkin, DJ-1, PINK1).

Main Results:

  • Multiple programmed cell death pathways, including apoptosis, autophagic cell death, and programmed necrosis, are involved in PD.
  • Key signaling molecules and pathways such as death receptors, BCL-2 family, caspases, PARP-1, and autophagy are relevant.
  • Evidence spans in vitro and in vivo studies across diverse PD models.

Conclusions:

  • Programmed cell death is a central mechanism in Parkinson's disease pathogenesis.
  • A comprehensive understanding of diverse PCD pathways is essential for developing effective PD treatments.
  • Further research into these pathways may reveal novel therapeutic targets for neuroprotection in PD.