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Gold nanoparticles elevate plasma testosterone levels in male mice without affecting fertility
Wen-Qing Li1, Feng Wang, Zhi-Min Liu
1Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, PR China.
Small (Weinheim an Der Bergstrasse, Germany)
|August 23, 2012
Abstract:
ω-Methoxy and ω-aminoethyl poly(ethylene glycol)-modified 14-nm gold nanoparticles can accumulate in mouse testes, pass through the blood-testis barrier, and enter germ cells. Furthermore, PEG-NH2 @AuNP accumulate more easier in the testes and increase plasma T levels. However, these two gold nanoparticle types have no effect on male fertility, fetal survival, or fetal development.

