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Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...

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Related Experiment Video

Updated: May 19, 2026

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

Routine screening for methicillin-resistant Staphylococcus aureus.

Nancy A Parks1, Martin A Croce

  • 1Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA. nparks5@uthsc.edu

Surgical Infections
|August 24, 2012
PubMed
Summary
This summary is machine-generated.

Identifying asymptomatic methicillin-resistant Staphylococcus aureus (MRSA) carriers is costly and may not reduce infections. Targeted screening and standard infection control are key for preventing MRSA infections.

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Multiplex PCR Assay for Typing of Staphylococcal Cassette Chromosome Mec Types I to V in Methicillin-resistant Staphylococcus aureus
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Multiplex PCR Assay for Typing of Staphylococcal Cassette Chromosome Mec Types I to V in Methicillin-resistant Staphylococcus aureus

Published on: September 5, 2013

Related Experiment Videos

Last Updated: May 19, 2026

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

Multiplex PCR Assay for Typing of Staphylococcal Cassette Chromosome Mec Types I to V in Methicillin-resistant Staphylococcus aureus
09:03

Multiplex PCR Assay for Typing of Staphylococcal Cassette Chromosome Mec Types I to V in Methicillin-resistant Staphylococcus aureus

Published on: September 5, 2013

Area of Science:

  • Infectious Diseases
  • Public Health
  • Clinical Microbiology

Background:

  • Increasing prevalence of asymptomatic methicillin-resistant Staphylococcus aureus (MRSA) carriers (5%-10%) poses risks for skin and soft tissue infections, including surgical site infections (SSIs).
  • Asymptomatic carriers face a significantly higher risk (approximately 30-fold) of developing SSIs.

Purpose of the Study:

  • To evaluate the utility of identifying and eradicating asymptomatic MRSA carriers to reduce infection risk.
  • To assess the cost-effectiveness and accuracy of different screening methodologies.

Main Methods:

  • A review of English-language literature was conducted.
  • Polymerase chain reaction (PCR)-based screening was compared to conventional swab cultures for accuracy and speed.

Main Results:

  • Literature findings are conflicting regarding the effectiveness of carrier identification and intervention in reducing subsequent MRSA infections.
  • PCR-based screening is more accurate and rapid than traditional swab cultures but incurs higher costs.

Conclusions:

  • MRSA screening programs are expensive with questionable utility for universal application.
  • Targeted screening of high-risk populations may warrant further investigation.
  • Standard infection control, hand hygiene, and antimicrobial stewardship are fundamental for preventing MRSA infections.