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[Study in the killing effect of Myxoma virus to C6 glioma cell in vitro]
Meng Zang1, Qiu-Sheng Zhang, Shi-Jie Liang
1Department of neurosurgery, Shenzhen 2nd hospital, Shenzhen 518035, China.
Objective:
To evaluate the susceptibility of C6 glioma cells to Myxoma virus and the killing effect of Myxoma virus to the C6 glioma cells in vitro.
Methods:
C6 glioma cells were infected with myxoma virus, used death virus as the negative control, 5-FU as the positive control, DEMD as blank control. The number of living cells were counted every 24 h, and Western-Blot method, inverted microscope and MTT assay were applicated to observe the cell morphology and survival rate in each group.
Results:
The cell number were decreased rapidly in virus effected group and 5-FU group, with significant differences to the negative and blank control groups. And cells in virus effected group appeared cytopathic effect.
Conclusions:
C6 glioma cells were susceptible to myxoma virus and myxoma virus had killing effect to C6 glioma cells in vitro.
