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Facial onset sensorimotor neuronopathy syndrome: a case series
Dobrin Dobrev1, Richard J Barohn, Neil E Anderson
1Neuromuscular Section, Department of Neurology, The University of Kansas Medical Center, Kansas City, KS, USA.
Journal of Clinical Neuromuscular Disease
|August 28, 2012
Summary
Facial onset sensorimotor neuronopathy (FOSMN) is a rare neurological disorder. This study details the first case series of three women with FOSMN, expanding its known characteristics.
Area of Science:
- Neurology
- Neuroscience
- Rare Diseases
Background:
- Facial onset sensorimotor neuronopathy (FOSMN) is a recently identified neurological syndrome.
- It is characterized by progressive facial sensory changes and subsequent motor deficits.
- FOSMN has predominantly been reported in men.
Observation:
- This study presents a case series of three women diagnosed with FOSMN.
- The women experienced symptoms including facial numbness, dysphagia, dysarthria, and motor weakness.
- Neurophysiological findings revealed denervation in limb and tongue muscles, with abnormal blink reflexes.
Findings:
- This is the first case series documenting FOSMN in women.
- The findings expand the known clinical phenotype of FOSMN.
- Upper motor neuron signs and normal arm sensory nerve conduction were observed.
Implications:
- This research broadens the understanding of FOSMN's presentation across sexes.
- It highlights the importance of considering FOSMN in women with similar neurological symptoms.
- Further research is needed to explore the underlying mechanisms and potential treatments for FOSMN.
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