Related Experiment Video
Updated: May 19, 2026

06:46
Optimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse
Published on: July 25, 2025
Minimally invasive external mini-glaucoma shunt implantation without conjunctival dissection
Richard S Hoffman1, Alan S Crandall, David A Crandall
1*Drs Fine Hoffman & Packer LLC, Eugene, OR †John A. Moran Eye Center, University of Utah, Salt Lake City, UT ‡Henry Ford Health System, Detroit, MI.
Journal of Glaucoma
|August 28, 2012
Summary
A new minimally invasive technique for Ex-PRESS Glaucoma Filtration Device implantation avoids conjunctival surgery. This approach offers a potentially faster, safer method with reduced scarring for glaucoma patients.
Area of Science:
- Ophthalmology
- Surgical Innovation
- Glaucoma Management
Background:
- Traditional Ex-PRESS Glaucoma Filtration Device implantation involves conjunctival peritomy, scleral flap creation, and suture closure.
- This established technique carries risks of conjunctival wound leaks and significant scarring.
Purpose of the Study:
- To introduce and evaluate a novel, minimally invasive technique for Ex-PRESS shunt implantation.
- To assess the safety and efficacy of this new approach compared to the conventional method.
Main Methods:
- The new technique utilizes a scleral tunnel approach originating from a grooved clear corneal incision.
- This method bypasses the need for conjunctival dissection and subsequent closure.
Main Results:
- The minimally invasive technique eliminates the requirement for conjunctival dissection and closure.
- It inherently prevents conjunctival wound leaks by design.
- The procedure maintains partial thickness scleral coverage for the shunt.
Conclusions:
- This novel technique offers a potentially faster and safer alternative for Ex-PRESS shunt implantation.
- It may lead to reduced conjunctival scarring and improved patient outcomes in glaucoma surgery.
Related Concept Videos
Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...