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Autoimmune progesterone dermatitis: a case report.

Rachana George¹, Shawky Z A Badawy

¹Department of Obstetrics and Gynecology, Upstate Medical University, Syracuse, NY 13210, USA.

Case Reports in Obstetrics and Gynecology

|August 28, 2012

Summary

Autoimmune progesterone dermatitis is a rare cyclic allergy to progesterone causing skin issues like erythema multiforme. Treatment involves inhibiting ovulation to reduce progesterone levels and prevent symptoms.

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Area of Science:

Dermatology
Immunology
Endocrinology

Background:

Autoimmune progesterone dermatitis is a rare condition characterized by cyclic premenstrual allergic reactions.
It is triggered by progesterone produced during the luteal phase of the menstrual cycle.
Manifestations include erythema multiforme, eczema, urticaria, angioedema, and anaphylaxis.

Purpose of the Study:

To present a case of autoimmune progesterone dermatitis.
To highlight diagnostic criteria and treatment strategies for this rare condition.

Main Methods:

A case study of a 38-year-old woman with a history of G2P2002.
Diagnosis based on the cyclic nature of dermatitis correlating with the menstrual cycle.
Treatment involved oral contraceptive pills to inhibit ovulation.

Main Results:

The patient presented with erythema multiforme and urticarial rash one week prior to menses.
Symptoms resolved following treatment with oral contraceptive pills.
This outcome supports the diagnosis of progesterone autoimmunity.

Conclusions:

Autoimmune progesterone dermatitis diagnosis relies on the cyclical pattern of skin manifestations.
This pattern distinguishes it from other allergic or systemic diseases.
Inhibiting ovulation effectively reduces progesterone secretion, preventing symptom recurrence.