Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Propagation of Uncertainty from Systematic Error

Propagation of Uncertainty from Systematic Error

The atomic mass of an element varies due to the relative ratio of its isotopes. A sample's relative proportion of oxygen isotopes influences its average atomic mass. For instance, if we were to measure the atomic mass of oxygen from a sample, the mass would be a weighted average of the isotopic masses of oxygen in that sample. Since a single sample is not likely to perfectly reflect the true atomic mass of oxygen for all the molecules of oxygen on Earth, the mass we obtain from this particular...

Proofreading

Proofreading

Proofreading

Proofreading

Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore, it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
Errors During Replication are Corrected by the DNA Polymerase Enzyme

Genome Copying Errors

Genome Copying Errors

DNA replication is a well-evolved process that copies millions of base pairs with high fidelity during each cell division. Occasionally a wrong base or a long stretch of wrong bases may get added to the daughter strands. If the errors are left unchecked, cells might accumulate several mutations that might endanger their survival. Therefore, the copying errors are checked and repaired at three levels.

Restarting Stalled Replication Forks

Restarting Stalled Replication Forks

DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart, a...

Mismatch Repair

Mismatch Repair

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Prediction that conflicts with judgment: The low absolute likelihood effect.

Journal of experimental psychology. General·2025

Same author

Different methods elicit different belief distributions.

Journal of experimental psychology. General·2024

Same author

Does thinking about God increase acceptance of artificial intelligence in decision-making?

Proceedings of the National Academy of Sciences of the United States of America·2024

Same author

Evaluations are inherently comparative, but are compared to what?

Journal of personality and social psychology·2024

Same author

Once and Again: Repeated Viewing Affects Judgments of Spontaneity and Preparation.

Psychological science·2024

Same author

Reply to Shah et al. & Lynch et al.: In defense of replication.

Proceedings of the National Academy of Sciences of the United States of America·2023

Search research articles

Related Experiment Video

Updated: May 19, 2026

Generation and Coherent Control of Pulsed Quantum Frequency Combs

Generation and Coherent Control of Pulsed Quantum Frequency Combs

Published on: June 8, 2018

Correcting the past: failures to replicate ψ.

Jeff Galak¹, Robyn A LeBoeuf², Leif D Nelson³

¹Tepper School of Business.

Journal of Personality and Social Psychology

|August 29, 2012

Summary

This study failed to replicate retroactive facilitation of recall, a finding originally reported by Bem (2011). A meta-analysis of all replication attempts confirmed no significant effect, suggesting the phenomenon is not robust.

More Related Videos

Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies

Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies

Published on: May 9, 2019

Troubleshooting and Quality Assurance in Hyperpolarized Xenon Magnetic Resonance Imaging: Tools for High-Quality Image Acquisition

Troubleshooting and Quality Assurance in Hyperpolarized Xenon Magnetic Resonance Imaging: Tools for High-Quality Image Acquisition

Published on: January 5, 2024

Related Experiment Videos

Last Updated: May 19, 2026

Generation and Coherent Control of Pulsed Quantum Frequency Combs

Generation and Coherent Control of Pulsed Quantum Frequency Combs

Published on: June 8, 2018

Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies

Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies

Published on: May 9, 2019

Troubleshooting and Quality Assurance in Hyperpolarized Xenon Magnetic Resonance Imaging: Tools for High-Quality Image Acquisition

Troubleshooting and Quality Assurance in Hyperpolarized Xenon Magnetic Resonance Imaging: Tools for High-Quality Image Acquisition

Published on: January 5, 2024

Area of Science:

Cognitive Psychology
Parapsychology

Background:

Previous research by Bem (2011) suggested retroactive facilitation of recall.
This phenomenon implies that future events can influence past memory retrieval.

Purpose of the Study:

To rigorously replicate Bem's (2011) experiments on retroactive facilitation of recall.
To conduct a meta-analysis of all available replication attempts to assess the overall effect size.

Main Methods:

Seven experiments with a total of 3,289 participants were conducted, following the procedures of Bem (2011).
A comprehensive meta-analysis was performed on all reported replication attempts.

Main Results:

The current replication attempts failed to find evidence for retroactive facilitation of recall.
The meta-analysis revealed an average effect size (d = 0.04), which was not statistically different from zero.

Conclusions:

The findings do not support the existence of retroactive facilitation of recall as originally reported.
The lack of a robust effect across multiple studies and a meta-analysis suggests the phenomenon may not be reliable.