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Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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Krüppel-like factor 8 emerges as an important regulator of cancer

Satadru K Lahiri, Jihe Zhao

    American Journal of Translational Research
    |September 1, 2012
    PubMed

    Insights

    Krüppel-like factor 8 (KLF8) is overexpressed in human cancers, regulating tumor progression. This review summarizes KLF8's structure, function, and target genes, highlighting its potential as a cancer therapy target.

    Area of Science:

    • Molecular Biology
    • Oncology
    • Genetics

    Background:

    • Krüppel-like factor 8 (KLF8) is a transcription factor implicated in various cellular processes.
    • KLF8 is frequently overexpressed in multiple human cancers.
    • Its role in tumor progression makes it a significant area of cancer research.

    Purpose of the Study:

    • To review the current understanding of Krüppel-like factor 8 (KLF8) in the context of cancer.
    • To consolidate information on KLF8's structure, function, and regulatory mechanisms.
    • To highlight KLF8 as a potential therapeutic target in oncology.

    Main Methods:

    • Literature review of up-to-date studies on KLF8.
    • Synthesis of information regarding KLF8's structure and dual transcription factor activity.
    • Analysis of KLF8 target genes, expression, and modification mechanisms.

    Main Results:

    • KLF8 exhibits a dual role as a transcription factor.
    • Identified KLF8 target genes and their involvement in cancer.
    • Summarized mechanisms regulating KLF8 expression and post-translational modifications.
    • KLF8's overexpression correlates with tumor progression in various cancers.

    Conclusions:

    • KLF8 plays a critical role in the progression of several human cancers.
    • Understanding KLF8's multifaceted roles is crucial for developing targeted cancer therapies.
    • KLF8 represents a promising therapeutic target for future cancer treatment strategies.
    Keywords:
    Keywords: Krüppel-like factor 8 (KLF8)cancer

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