Related Experiment Video
Updated: May 19, 2026

Safety Precautions and Operating Procedures in an (A)BSL-4 Laboratory: 1. Biosafety Level 4 Suit Laboratory Suite Entry and Exit Procedures
Published on: October 3, 2016
Regulatory issues in accreditation of toxicology laboratories
1Department of Pathology, The Ohio State University, 4173 Graves Hall, 333 West 10th Avenue, Columbus OH 43210, USA. Michael.Bissell@osumc.edu
Abstract:
Clinical toxicology laboratories and forensic toxicology laboratories operate in a highly regulated environment. This article outlines major US legal/regulatory issues and requirements relevant to accreditation of toxicology laboratories (state and local regulations are not covered in any depth). The most fundamental regulatory distinction involves the purposes for which the laboratory operates: clinical versus nonclinical. The applicable regulations and the requirements and options for operations depend most basically on this consideration, with clinical toxicology laboratories being directly subject to federal law including mandated options for accreditation and forensic toxicology laboratories being subject to degrees of voluntary or state government–required accreditation.
Related Concept Videos
Toxicity Testing in Animals
Drug Regulation
Toxicokinetics: Overview
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Drug Control Governance: Regulatory Bodies and Their Impact
Drug Toxicity: Overview

