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Multiple oral squamous cell carcinomas associated with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy
Martina K Shephard1, Mark Schifter, Carsten E Palme
1Concord Repatriation General Hospital, Concord, Sydney, New South Wales, Australia.
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
|September 4, 2012
Summary
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) patients with chronic oral candidiasis face an increased risk of early-onset oral cancer. This case highlights multiple oral squamous cell carcinomas in an APECED patient, emphasizing the need for vigilant monitoring.
Area of Science:
- Immunology
- Genetics
- Oncology
Background:
- Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare autosomal recessive disorder.
- Key features include chronic mucocutaneous candidiasis, hypoparathyroidism, and adrenal insufficiency.
- Chronic oral candidiasis is often the initial clinical sign.
Observation:
- This report details a case of multiple oral squamous cell carcinomas in a 35-year-old woman with APECED.
- The patient presented with chronic mucocutaneous candidiasis as part of her APECED.
- She has been diagnosed with three confirmed oral squamous cell carcinomas.
Findings:
- The patient's oral squamous cell carcinomas were managed via laser resection and ablation.
- She is currently undergoing systemic antifungal therapy.
- Regular surveillance is conducted within a multidisciplinary head and neck clinic.
Implications:
- Chronic oral candidal infection may play a role in oral carcinogenesis within the APECED population.
- Early detection and management are crucial for patients with APECED and oral candidiasis.
- This case underscores the importance of multidisciplinary care for managing complex APECED-related conditions.
