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Pentanidium-catalyzed enantioselective α-hydroxylation of oxindoles using molecular oxygen
Yuanyong Yang1, Farhana Moinodeen, Willy Chin
1Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
Abstract:
Pentanidium-catalyzed α-hydroxylation of 3-substituted-2-oxindoles using molecular oxygen has been developed with good yields and enantioselectivities. This reaction does not require an additional reductant such as triethyl phosphite, which was typically added to reduce the peroxide intermediate. The reaction was demonstrated to consist of two-steps: an enantioselective formation of hydroperoxide oxindole and a kinetic resolution of the hydroperoxide oxindole via reduction with enolates generated from the oxindoles.
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