Related Experiment Video
Updated: May 19, 2026
07:32
Synthesis of Hydrogels with Antifouling Properties As Membranes for Water Purification
Published on: April 7, 2017
Macroporous PHEMA-based cryogel discs for bilirubin removal.
Işık Perçin1, Gözde Baydemir, Bahar Ergün
1Department of Biology, Molecular Biology Division, Hacettepe University, Ankara, Turkey.
Artificial Cells, Nanomedicine, and Biotechnology
|September 6, 2012
Summary
A novel poly(hydroxyethyl methacrylate) cryogel disc containing N-methacryloyl-L-tryptophan methyl ester effectively removes bilirubin from human plasma, demonstrating a high adsorption capacity.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Biomedical Engineering
Background:
- Bilirubin (BR) accumulation in plasma is a concern in certain medical conditions.
- Effective methods for bilirubin removal from human plasma are needed.
Purpose of the Study:
- To develop and characterize a novel poly(hydroxyethyl methacrylate) cryogel disc (PHEMATrp) for bilirubin removal.
- To evaluate the bilirubin adsorption capacity of the PHEMATrp cryogel disc.
Main Methods:
- Synthesis of PHEMATrp cryogel disc via bulk polymerization.
- Characterization using swelling tests, SEM, elemental analysis, BET analysis, contact angle, and surface energy calculations.
- Bilirubin adsorption studies in a batch system.
Main Results:
- High gelation yield of up to 92% achieved.
- PHEMATrp cryogel disc exhibited significant bilirubin adsorption capacity.
- Maximum bilirubin adsorption capacity was determined to be 22.2 mg/g cryogel disc.
Conclusions:
- The developed PHEMATrp cryogel disc is a promising material for bilirubin removal from human plasma.
- The material shows potential for applications in extracorporeal therapies.
