Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

GPCRs Regulate Adenylyl Cylase Activity

GPCRs Regulate Adenylyl Cylase Activity

Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of cells.
Two...

Structure of Cadherins

Structure of Cadherins

The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins” is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This diversity of cadherins...

G Protein-coupled Receptors

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...

Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation

Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation

Inductively coupled plasma (ICP) is the common plasma source used in atomic emission spectroscopy (AES), a technique that detects and analyzes various elements in a sample. This method is often called inductively coupled plasma atomic emission spectroscopy (ICP-AES).
There are three main types of inductively coupled plasma atomic emission spectroscopy (ICP-AES) instruments: sequential, simultaneous multichannel, and Fourier transform instruments, with the latter being less commonly used.

Transducer Mechanism: G Protein–Coupled Receptors

Transducer Mechanism: G Protein–Coupled Receptors

G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical, 7TM, or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Enhancement of reactive oxygen species production by ultra-short electron pulses.

Royal Society open science·2024

Same author

ASSESSMENT OF INTEGRITY AND LEAD-EQUIVALENCE OF SHIELDED GARMENTS USING TWO-DIMENSIONAL X-RAY IMAGES FROM A COMPUTED TOMOGRAPHY SCANNER.

Radiation protection dosimetry·2021

Same author

Patient-specific quality assurance on a Varian Halcyon linear accelerator using a PTW Octavius 4D device.

Physical and engineering sciences in medicine·2021

Same author

A Monte Carlo model of synchrotron radiotherapy shows good agreement with experimental dosimetry measurements: Data from the imaging and medical beamline at the Australian Synchrotron.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2020

Same author

Monte Carlo calculated output correction factors for Gafchromic EBT3 film for relative dosimetry in small stereotactic radiosurgery fields.

Physical and engineering sciences in medicine·2020

Same author

A very low diffusion Fricke gel dosimeter with functionalised xylenol orange-PVA (XOPVA).

Physics in medicine and biology·2019

Same journal

A comparison between EPSON V700 and EPSON V800 scanners for film dosimetry.

Australasian physical & engineering sciences in medicine·2020

Same journal

Nanodosimetric understanding to the dependence of the relationship between dose-averaged lineal energy on nanoscale and LET on ion species.

Australasian physical & engineering sciences in medicine·2020

Same journal

Schizophrenia diagnosis using innovative EEG feature-level fusion schemes.

Australasian physical & engineering sciences in medicine·2020

Same journal

Force decoding using local field potentials in primary motor cortex: PLS or Kalman filter regression?

Australasian physical & engineering sciences in medicine·2020

Same journal

EPSM 2019, Engineering and Physical Sciences in Medicine : 28-30 October 2019, Perth, Australia.

Australasian physical & engineering sciences in medicine·2020

Same journal

New name: Physical and Engineering Sciences in Medicine.

Australasian physical & engineering sciences in medicine·2020

See all related articles

Search research articles

Related Experiment Video

Updated: May 18, 2026

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation

Published on: September 4, 2017

A CAD interface for GEANT4.

C M Poole¹, I Cornelius, J V Trapp

¹Cancer Care Services, Royal Brisbane and Womens Hospital, Herston, QLD, 4029, Australia. christopher.poole@qut.edu.au

Australasian Physical & Engineering Sciences in Medicine

|September 8, 2012

Summary

This summary is machine-generated.

This study introduces a new method for directly importing CAD geometries into GEANT4 simulations, bypassing complex conversions. This approach simplifies the simulation workflow for complex components without requiring commercial software.

More Related Videos

User-friendly, High-throughput, and Fully Automated Data Acquisition Software for Single-particle Cryo-electron Microscopy

User-friendly, High-throughput, and Fully Automated Data Acquisition Software for Single-particle Cryo-electron Microscopy

Published on: July 29, 2021

gP2S, an Information Management System for CryoEM Experiments

gP2S, an Information Management System for CryoEM Experiments

Published on: June 10, 2021

Related Experiment Videos

Last Updated: May 18, 2026

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation

Published on: September 4, 2017

User-friendly, High-throughput, and Fully Automated Data Acquisition Software for Single-particle Cryo-electron Microscopy

User-friendly, High-throughput, and Fully Automated Data Acquisition Software for Single-particle Cryo-electron Microscopy

Published on: July 29, 2021

gP2S, an Information Management System for CryoEM Experiments

gP2S, an Information Management System for CryoEM Experiments

Published on: June 10, 2021

Area of Science:

Physics simulation
Computational geometry

Background:

GEANT4 simulations often require complex geometries.
Direct import of CAD models into GEANT4 is limited.
Existing workarounds involve commercial software and file conversion.

Purpose of the Study:

To present a novel technique for direct CAD model import into GEANT4.
To eliminate the need for commercial software and intermediate file formats.

Main Methods:

Developed a direct interface for loading CAD models.
Tested the interface with diverse and complex CAD models.

Main Results:

The developed technique successfully imported all tested CAD models directly.
No import errors were encountered during testing.
GEANT4 successfully navigated all imported geometries.

Conclusions:

The new method provides a robust and efficient way to integrate CAD geometries into GEANT4.
This technique simplifies the simulation setup for complex components.