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Related Experiment Video

Updated: May 18, 2026

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization

Published on: June 4, 2020

Thromboelastography: might work in neonatology too?

M Radicioni¹, D Mezzetti, A Del Vecchio

¹Neonatal Intensive Care - Paediatric Clinic, S. Maria della Misericordia Hospital of Perugia, Perugia, Italy. maurizio.radicioni@gmail.com

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

|September 11, 2012

Summary

Thromboelastography (TEG) and Rotational Thromboelastometry (ROTEM) show potential for neonatal intensive care units, but more research is needed to confirm their reliability for diagnosing and guiding treatment in newborns.

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Transcutaneous Microcirculatory Imaging in Preterm Neonates

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

Area of Science:

Coagulation science
Neonatal intensive care
Point-of-care testing

Background:

Neonatal hemostasis differs from adults, with accelerated initiation and propagation of coagulation.
Standard coagulation tests may not fully reflect the hemostatic status of newborns.
Limited data exists on viscoelastic hemostatic assays in neonatal populations, especially premature infants.

Purpose of the Study:

To review the working principles of thromboelastography (TEG) and rotational thromboelastometry (ROTEM).
To evaluate the current knowledge on implementing TEG/ROTEM in the neonatal intensive care unit (NICU).

Main Methods:

A comprehensive literature search of the PubMed database was conducted.
The search focused on studies published until May 31, 2012, regarding TEG/ROTEM use in newborn infants.

Main Results:

Neonatal data is scarce, primarily from healthy subjects, with minimal information on extremely premature infants.
Healthy newborns demonstrate age-dependent accelerated coagulation initiation and propagation.
Clot firmness and fibrinolysis in newborns are comparable to adults, despite prolonged standard coagulation tests.
Pathological conditions like sepsis and hypothermia significantly alter thromboelastographic parameters in neonates.

Conclusions:

Current data is insufficient to definitively establish the reliability of viscoelastic point-of-care analyzers in the NICU.
Viscoelastic testing holds potential as a diagnostic tool and for guiding transfusion therapy in neonates.
Further research is warranted to explore the clinical utility and reliability of these assays in the NICU setting.