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Updated: May 18, 2026
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A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
Published on: November 30, 2021
Haematological abnormalities in neonatal necrotizing enterocolitis.
Rhonnie Song1, Girish C Subbarao, Akhil Maheshwari
1Department of Pediatrics, Division of Neonatology, University of Illinois at Chicago, Chicago, IL 60612, USA.
Summary
Necrotizing enterocolitis (NEC) in preterm infants is linked to significant blood abnormalities. These hematological issues, including low platelets and abnormal white blood cell counts, are common in NEC.
Area of Science:
- Neonatalogy
- Hematology
Background:
- Necrotizing enterocolitis (NEC) is a major cause of illness and death in premature infants.
- Infants born before 32 weeks gestation or weighing under 1500 grams are at highest risk.
Purpose of the Study:
- To review the hematological abnormalities associated with NEC.
- To explore the role of these abnormalities in NEC pathogenesis and prognosis.
Main Methods:
- A comprehensive literature search was conducted.
- Databases searched included PubMed, EMBASE, and Scopus.
- Abstracts from Pediatric Academic Societies' meetings were also reviewed.
Main Results:
- Frequent hematological findings in NEC include thrombocytopenia (low platelets).
- Disseminated intravascular coagulation (DIC) is also observed.
- Abnormal neutrophil counts (high or low) and hemolytic anemia are common.
Conclusions:
- NEC is frequently accompanied by various hematological abnormalities.
- These blood-related issues may contribute to gut mucosal injury in NEC.
- Hematological status in NEC can provide important prognostic insights.
