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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
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The empirical approach to drug therapy optimization relies on correlating pharmacological response with administered dosage. Such an approach can be costly, time-consuming, and often yields poor correlation due to variables like formulation factors and drug elimination characteristics. A more precise approach correlates response with plasma drug concentration or the amount of drug in the body, rather than dosage. This is achieved through pharmacokinetic-pharmacodynamic (PK/PD) modeling, which...
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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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Published on: December 11, 2016

Reducing cost by reducing polypharmacy: the polypharmacy outcomes project.

Gotaro Kojima1, Christina Bell, Bruce Tamura

  • 1John A. Hartford Foundation Center of Excellence in Geriatrics, Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96817, USA. gotarokojima@yahoo.co.jp

Journal of the American Medical Directors Association
|September 11, 2012
PubMed
Summary
This summary is machine-generated.

Geriatric medicine fellows and a geriatrician reduced polypharmacy costs in long term care residents. This intervention significantly lowered overall, scheduled, and PRN medication expenses, particularly for gastrointestinal and CNS drugs.

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Area of Science:

  • Geriatric Medicine
  • Pharmacoeconomics
  • Long Term Care

Background:

  • Polypharmacy is prevalent in long term care residents, increasing medication costs and potential adverse events.
  • Interventions targeting medication review and deprescribing are crucial for optimizing care in this population.

Purpose of the Study:

  • To evaluate the impact of a geriatric medicine fellow and geriatrician intervention on medication costs among long term care residents with polypharmacy.
  • To assess the effectiveness of using Beers Criteria and drug-drug interaction programs in reducing medication expenses.

Main Methods:

  • An interventional study was conducted in a hospital-affiliated long term care facility.
  • Medication lists of residents on 9 or more medications were reviewed using the 2003 Beers Criteria and Epocrates.
  • Recommendations were made to primary physicians, who determined medication changes.

Main Results:

  • The intervention group included 70 residents with polypharmacy.
  • Mean monthly medication costs per resident significantly decreased post-intervention (overall: $874.27 to $843.56; scheduled: $814.05 to $801.14; PRN: $60.22 to $42.43).
  • Highest cost savings were observed in gastrointestinal, central nervous system-active, analgesic, and diabetes medications.

Conclusions:

  • Physician-led polypharmacy reduction interventions can significantly decrease medication costs in long term care.
  • This intervention provided valuable training for geriatric medicine fellows in practice-based learning and systems-based practice.
  • Utilizing readily available tools like Beers Criteria and drug interaction programs is effective for cost-saving medication management.