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Updated: May 18, 2026

Functional Characterization of Endogenously Expressed Human RYR1 Variants
Published on: June 9, 2021
[Riga-Fede disease]
J Marie1, J-C Fricain, F Boralevi
1Unité de dermatologie pédiatrique, hôpital Pellegrin, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France. gerome mar@yahoo.fr
Introduction:
Riga-Fede disease is a benign affection of the oral mucosa which has been poorly described in the literature. This entity of unknown ethiopathogenicity is sometimes revealing of dysautonomic or neuropsychic disorders. We report a new case.
Case Report:
A 10-month-old girl was referred to us for a unique deep ulceration of the lower lingual apex, in a context of right basal pneumopathy. Samples were negative for bacteriological, virological and mycological analysis. After successful treatment of the pneumopathy, the ulceration was unchanged and we diagnosed Riga-Fede disease.
Discussion:
Our observation is representative of the Riga-Fede cases previously described in the literature, comparing the age of onset, the topography and the ulceration type. We did not diagnose any dysautonomic or neuropsychic disorder as reported in some cases. Suppression of the lingual trauma resulted in healing of the ulceration.
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