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Updated: May 18, 2026
07:59
Functional Characterization of Endogenously Expressed Human RYR1 Variants
Published on: June 9, 2021
[Riga-Fede disease].
J Marie1, J-C Fricain, F Boralevi
1Unité de dermatologie pédiatrique, hôpital Pellegrin, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France. gerome mar@yahoo.fr
Annales De Dermatologie Et De Venereologie
|September 12, 2012
Summary
Riga-Fede disease, a rare oral condition, typically presents as a lingual ulcer. This case highlights its benign nature and resolution upon removal of the traumatic cause.
Area of Science:
- Oral Medicine
- Pediatric Dentistry
- Dermatology
Background:
- Riga-Fede disease is an underreported benign oral mucosal condition.
- Its etiology remains unclear, though it may indicate underlying dysautonomic or neuropsychic issues.
- This report details a novel case for better understanding.
Observation:
- A 10-month-old infant presented with a deep ulcer on the tongue's apex.
- The ulcer persisted despite treatment for a concurrent right basal pneumopathy.
- Bacteriological, virological, and mycological samples were negative.
Findings:
- The case aligns with existing literature on Riga-Fede disease regarding age, location, and ulcer characteristics.
- No dysautonomic or neuropsychic disorders were identified in this patient.
- Healing occurred after eliminating the lingual trauma.
Implications:
- This case reinforces the diagnosis of Riga-Fede disease in infants with similar presentations.
- It underscores the importance of identifying and removing the traumatic etiology for successful treatment.
- Further research may elucidate the precise pathogenesis and associated systemic conditions.
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