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Effect of thyroid deficiency on actin mRNA content in the developing rat cerebellum
C Faivre-Sarrailh1, C Ferraz, J P Liautard
1CNRS URA 1197, Université des Sciences et Techniques du Languedoc, Montpellier, France.
Abstract:
The actin mRNA content of the cerebellum was determined in normal and hypothyroid developing rats using RNA dot hybridization with a beta-actin cDNA probe. The decline in actin mRNA content occurring during the second postnatal week in normal development was delayed by about 1 week in hypothyroid rats. Since this effect coincides exactly with the delay in actin filament formation recently reported in thyroid-deficient rats, it strengthens the hypothesis of an inverse relationship in the developing brain between the polymerization state of actin and the production of actin mRNA.