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Updated: May 18, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
[Treatment of prolonged migraine attack (status migrenosus)]
1HYKS, neurologian klinikka.
Abstract:
If a migraine attack takes more than 72 hours it is called status migrenosus (SM). The most important contributing factor in SM is prolonged excessive use of anti-migraine drugs. Before starting any treatments for SM, severe causes underlying the prolonged pain should be excluded. The cornerstones of pharmacological therapy for SM are parenterally administered anti-inflammatory drugs and triptans as well as valproate and dopamine antagonists. With regard to long-term prognosis, the recognition and treatment of medication overuse headache is essential.
Insights
Status migrainosus (SM) is a migraine attack lasting over 72 hours, often caused by excessive medication use. Effective treatment involves excluding severe causes, using specific medications, and managing medication overuse headache for better long-term outcomes.
Area of Science:
- Neurology
- Pharmacology
Context:
- Status migrainosus (SM) is defined as a debilitating migraine attack exceeding 72 hours.
- Prolonged and excessive use of anti-migraine medications is a primary contributing factor to SM.
- Exclusion of severe underlying causes is a critical prerequisite for initiating SM treatment.
Purpose:
- To outline the key diagnostic considerations and therapeutic strategies for managing status migrainosus.
- To emphasize the importance of addressing medication overuse headache in the long-term prognosis of SM.
Summary:
- Pharmacological management of SM includes parenteral anti-inflammatory drugs, triptans, valproate, and dopamine antagonists.
- Long-term prognosis is significantly improved by recognizing and treating associated medication overuse headache.
Impact:
- Provides a concise overview of SM management for clinicians.
- Highlights the crucial role of addressing medication overuse in preventing chronic migraine conditions.
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