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Score Study Report 12: Development of venous collaterals in the Score Study
David V Weinberg1, Aimee E Wahle, Michael S Ip
1Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Retina (Philadelphia, Pa.)
|September 14, 2012
Summary
Venous collaterals in retinal vein occlusion did not show a link to visual acuity. Intravitreal corticosteroid treatment also did not affect the development of these new blood vessels.
Area of Science:
- Ophthalmology
- Retinal Vascular Diseases
Background:
- Retinal vein occlusion (RVO) encompasses both branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO).
- Venous collaterals are newly formed blood vessels that can develop after RVO.
- The clinical significance and prognostic value of venous collaterals in RVO remain areas of active investigation.
Purpose of the Study:
- To determine the prevalence of venous collaterals following BRVO and CRVO.
- To assess the relationship between venous collaterals and clinical factors, including visual acuity.
- To evaluate the impact of intravitreal corticosteroid treatment on the development of new venous collaterals.
Main Methods:
- Analysis of data from two multicenter randomized clinical trials within the Standard of Care versus COrticosteroid for REtinal Vein Occlusion (SCORE) Study.
- Retrospective review of patient data, including baseline and follow-up clinical features and treatment regimens.
Main Results:
- No statistically significant association was found between the presence of venous collaterals and visual acuity at baseline or during follow-up.
- Treatment with intravitreal triamcinolone acetonide did not demonstrate a significant influence on the development of new venous collaterals.
Conclusions:
- Contrary to some prior research, venous collateral development in eyes with BRVO or CRVO did not independently correlate with visual acuity outcomes in the SCORE Study.
- Intravitreal steroid administration does not appear to impact the formation of venous collaterals in RVO.
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