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Co-processed excipients: a patent review
Nidhi Garg1, Harish Dureja, Deepak Kaushik
1Department of Pharmaceutical Sciences, M.D. University, Rohtak, India.
Recent Patents on Drug Delivery & Formulation
|September 15, 2012
Summary
Co-processed excipients enhance tablet manufacturing by improving flow and compressibility. This review explores their advantages, methods, and increasing patent activity in the pharmaceutical industry.
Area of Science:
- Pharmaceutical Science
- Materials Science
Background:
- High-speed tableting and direct compression demand improved excipient functionality, particularly flowability and compressibility.
- Co-processed excipients, formed via sub-particle interactions, offer enhanced properties and overcome limitations of individual excipients.
Purpose of the Study:
- To review co-processed excipients and their applications in the pharmaceutical industry.
- To analyze patent trends and discuss advantages, limitations, selection criteria, processing methods, and regulatory aspects.
Main Methods:
- Systematic search of European and United States patent databases.
- Review and synthesis of patent literature and scientific publications on co-processed excipients.
Main Results:
- Co-processed excipients demonstrate synergistic improvements in physical and chemical properties.
- A significant increase in patent filings highlights the growing industrial interest and innovation in this area.
- Co-processing offers regulatory advantages due to the absence of chemical changes.
Conclusions:
- Co-processed excipients are a valuable tool for developing high-functionality pharmaceutical dosage forms.
- Further research and development in co-processing techniques are expected, driven by pharmaceutical industry needs and patent activity.
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