[Advances in the structure and function of pandemic A/H1N1/2009 influenza virus HA protein]
Wen-Qiang Zhang1, Shao-Xia Song, Tong-Zhan Wang
1Shandong Center for Disease Control and Prevention, Shandong Provincial Key Laboratory of Disease Control and Prevention, Shandong University Institute for Prevention Medicine, Jinan 250014, China. wenqiang782002@yahoo.com.cn
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The pandemic A/H1N1/2009 influenza virus, a significant global health threat, is reviewed. This paper focuses on the hemagglutinin (HA) protein
Area of Science:
- Virology
- Immunology
- Molecular Biology
Abstract:
Since March 2009, pandemic A/H1N1/2009 influenza virus has been spreading throughout many countries including China. The emerged virus caused great harm to human health and social economy. Hemagglutinin (HA) is the most important viral surface glycoprotein, mainly possessing three kinds of functions: (1) binding to host cell receptor, (2) triggering the fusion between viral envelop and target cell membrane, (3) stimulating the body to generate the neutralizing antibody. Advances in the structure, primary function, evolution and antigenicity of pandemic A/H1N1/2009 influenza virus HA protein are reviewed in this paper.
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