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From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Polyketide metabolites from the endophytic fungus Microdiplodia sp. KS 75-1
Yoshihito Shiono1, Taiji Hatakeyama, Tetsuya Murayama
1Department ofFood, Life, and Environmental Science, Faculty ofAgriculture Yamagata University, Tsuruoka, Yamagata 997-8555, Japan. yshiono@tdsl.tr.yamagata-u.ac.jp
Abstract:
Through our screening for new natural compounds, four new polyketide metabolites, 7,8-dihydonivefuranone A (1), 6(7)-dehydro-8-hydroxyterrefuranone (2), 8-hydroxyterrefuranone (3), and 6-hydroxyterrefuranone (4) were isolated from the fermentation extract of Microdiplodia sp. KS 75-1, together with the known compounds nivefuranones A (5) and B (6); their structures were determined by spectroscopic (NMR, UV and IR) and MS analysis. Compounds 1, 2, 4 and 5 showed antimicrobial activity against Candida albicans and Staphylococcus aureus.
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