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Pathophysiology of systolic and diastolic heart failure

Kanu Chatterjee1

  • 1Division of Cardiology, Department of Medicine, University of Iowa, Iowa city, IA 52242-1081, USA. kanu-chatterjee@uiowa.edu

The Medical Clinics of North America
|September 18, 2012
PubMed

Insights

Systolic heart failure involves impaired left ventricular function and increased mass, often driven by neurohormonal activation. This remodeling contributes to the progression of chronic heart failure.

Area of Science:

  • Cardiology
  • Heart Failure Pathophysiology

Background:

  • Chronic heart failure presents as two main subsets: systolic and diastolic.
  • Systolic heart failure is characterized by depressed left ventricular (LV) Starling function.

Purpose of the Study:

  • To summarize key pathophysiologic mechanisms in systolic heart failure.
  • To highlight methods for assessing LV mass in heart failure.

Main Methods:

  • Review of established knowledge on systolic heart failure.
  • Mention of transthoracic echocardiography and cardiac magnetic resonance imaging for LV mass measurement.

Main Results:

  • Systolic heart failure exhibits increased left ventricular mass.
  • Neurohormonal activation is a key driver of ventricular remodeling and disease progression.

Conclusions:

  • Understanding LV mass and neurohormonal activation is crucial for managing systolic heart failure.
  • Advanced imaging techniques improve assessment of cardiac structure in heart failure.

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