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Related Concept Videos

Double Resonance Techniques: Overview01:12

Double Resonance Techniques: Overview

Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
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Gain01:15

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Gain:
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Interference: Path Lengths01:10

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Related Experiment Video

Updated: May 18, 2026

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans
08:25

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

Published on: May 19, 2016

A method for event-related phase/amplitude coupling.

Bradley Voytek1, Mark D'Esposito, Nathan Crone

  • 1Helen Wills Neuroscience Institute, University of California, Berkeley, USA. bradley.voytek@gmail.com

Neuroimage
|September 19, 2012
PubMed
Summary
This summary is machine-generated.

Phase/amplitude coupling (PAC) measures neuronal communication but current methods lack temporal resolution. We introduce event-related PAC (ERPAC) to capture dynamic, sub-second changes in brain communication across events.

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Infant Auditory Processing and Event-related Brain Oscillations
06:34

Infant Auditory Processing and Event-related Brain Oscillations

Published on: July 1, 2015

Related Experiment Videos

Last Updated: May 18, 2026

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans
08:25

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

Published on: May 19, 2016

Infant Auditory Processing and Event-related Brain Oscillations
06:34

Infant Auditory Processing and Event-related Brain Oscillations

Published on: July 1, 2015

Area of Science:

  • Neuroscience
  • Electrophysiology
  • Computational Neuroscience

Background:

  • Phase/amplitude coupling (PAC) is a key electrophysiological measure for understanding neuronal communication.
  • Existing PAC calculation methods yield average values over extended periods, limiting temporal precision.
  • Current techniques necessitate block designs and temporal concatenation, sacrificing sub-second resolution.

Purpose of the Study:

  • To develop a novel method for calculating event-related phase/amplitude coupling (ERPAC).
  • To enable the capture of temporal dynamics in PAC related to specific events or tasks.
  • To provide a tool applicable to human and animal electromagnetic recordings.

Main Methods:

  • Developed a new algorithm for calculating event-related phase/amplitude coupling (ERPAC).
  • The method is designed to analyze PAC changes across discrete events.
  • Applicable to various electromagnetic recording modalities in humans and animals.

Main Results:

  • The ERPAC method allows for the temporal evolution of PAC to be tracked.
  • Enables analysis of task-related changes in neural communication.
  • Provides high temporal resolution for PAC analysis.

Conclusions:

  • ERPAC offers a significant advancement over traditional PAC methods.
  • This technique enhances the study of dynamic neuronal communication.
  • Facilitates a deeper understanding of brain function with high temporal fidelity.