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Related Experiment Videos

Systemic amyloidosis in a mare.

T B Hawthorne1, B Bolon, D J Meyer

  • 1Department of Medical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610.

Journal of the American Veterinary Medical Association
|January 15, 1990
PubMed
Summary
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This study details a rare case of equine amyloidosis in a mare, presenting with skin nodules and internal masses. Cytologic findings of multinucleated giant cells and eosinophilic material may indicate amyloidosis.

Area of Science:

  • Veterinary Pathology
  • Comparative Pathology

Background:

  • Amyloidosis, characterized by extracellular deposition of misfolded proteins, can affect various organs.
  • Equine amyloidosis is uncommon, with AA (secondary) amyloidosis being the most frequently reported type.

Observation:

  • A mare presented with chronic cachexia, multiple skin nodules, abdominal masses, and enlarged lymph nodes.
  • Cytologic examination of skin nodules revealed multinucleated giant cells surrounding eosinophilic material.
  • Histopathology confirmed extensive amyloid deposits in masses, lymph nodes, and multiple organs.

Findings:

  • The amyloid deposits retained congophilia after potassium permanganate oxidation, suggesting non-AA (primary) amyloid fibrils.
  • The mare exhibited both systemic (visceral) and organ-limited (cutaneous) forms of amyloidosis, a rare presentation in horses.

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  • The presence of multinucleated giant cells with eosinophilic material in cytologic samples is a potential diagnostic indicator for equine amyloidosis.

    • Implications:

    • This case highlights the rare occurrence of primary amyloidosis in horses.
    • Cytologic findings can aid in the early suspicion and diagnosis of amyloidosis in horses.
    • Understanding the different forms of equine amyloidosis is crucial for accurate diagnosis and management.