Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A DNA Methylation-based algorithm Improves Lung Cancer risk prediction in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial.

Lung cancer (Amsterdam, Netherlands)·2026
Same author

Pilot Evaluation of the Biopsychosocial Screening Inventory for Fragile X Syndrome (BIPSSI-FX) with an Extended African American Family.

Journal of theory construction & testing·2026
Same author

A Two-Track Model of Huntington's Disease Pathology: Striatal Atrophy Mediates Maladaptive Immune Dysregulation.

International journal of molecular sciences·2026
Same author

Pediatric TeleSANE: A Discussion of the Appropriateness, Feasibility, and Recommendations for Expanding Access to Medical Forensic Care for Prepubescents.

Journal of forensic nursing·2026
Same author

Methylation Biomarker of Chronic Heavy Alcohol Consumption (HAC), but Not Acute HAC, Predicts All-Cause Mortality in Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial.

Genes·2026
Same author

Shape matters: Predicting Huntington's disease using progression modelling.

Computer methods and programs in biomedicine·2026

Related Experiment Video

Updated: May 18, 2026

Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System
10:52

Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System

Published on: December 10, 2021

Development of the Huntington disease work function scale.

Bradley Brossman1, Janet K Williams, Nancy Downing

  • 1American Board of Internal Medicine, Philadelphia, PA, USA.

Journal of Occupational and Environmental Medicine
|September 22, 2012
PubMed
Summary

A new Huntington disease Work Function (HDWF) measure helps assess workplace needs for individuals with prodromal HD. This tool aids in identifying necessary accommodations for managing work capacity.

More Related Videos

Assessing Functional Performance in the Mdx Mouse Model
10:32

Assessing Functional Performance in the Mdx Mouse Model

Published on: March 27, 2014

A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease
05:39

A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease

Published on: June 13, 2025

Related Experiment Videos

Last Updated: May 18, 2026

Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System
10:52

Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System

Published on: December 10, 2021

Assessing Functional Performance in the Mdx Mouse Model
10:32

Assessing Functional Performance in the Mdx Mouse Model

Published on: March 27, 2014

A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease
05:39

A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease

Published on: June 13, 2025

Area of Science:

  • Neuroscience
  • Occupational Health
  • Psychometrics

Background:

  • Huntington disease (HD) significantly impacts work function.
  • Prodromal HD presents unique challenges for maintaining employment.
  • A specific tool is needed to assess work capacity in this population.

Purpose of the Study:

  • To develop and validate a work function measure tailored for individuals with prodromal Huntington disease (HD).
  • To create a tool that assists in determining appropriate workplace accommodations.

Main Methods:

  • The Huntington disease Work Function (HDWF) measure was developed using focus groups and expert validation.
  • Pilot studies involved individuals with prodromal HD, their companions, and controls.
  • Psychometric properties including internal consistency, interrater reliability, and convergent validity were assessed.

Main Results:

  • The HDWF demonstrated acceptable internal consistency (Cronbach α = 0.77) and interrater reliability (r = 0.58).
  • Convergent validity was supported by correlations with established measures of productivity, social adjustment, and cognition.
  • The HDWF effectively differentiated between individuals with prodromal HD and those without (P < 0.0001).

Conclusions:

  • The HDWF is a brief, self-administered assessment tool.
  • It shows potential for monitoring work function in individuals with prodromal HD.
  • This measure can aid in managing employment and workplace adjustments.