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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Chronic Bowel Disorders: Introduction

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Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
Inflammatory Bowel Disease I: Introduction01:26

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Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...

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Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
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Bickerstaff's brainstem encephalitis associated with ulcerative colitis.

Miyuki Yamamoto1, Ryota Inokuchi, Kensuke Nakamura

  • 1Department of Emergency and Critical Care Medicine, The University of Tokyo Hospital, Tokyo, Japan.

BMJ Case Reports
|September 25, 2012
PubMed
Summary
This summary is machine-generated.

Bickerstaff

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Area of Science:

  • Neurology
  • Immunology

Background:

  • Ulcerative colitis (UC) patients are at higher risk for neurological complications.
  • Campylobacter infections are a known trigger for Bickerstaff's brainstem encephalitis (BBE).

Observation:

  • A 25-year-old Japanese male with UC presented with cold and digestive symptoms, followed by ascending hypoesthesia and altered consciousness.
  • Physical examination revealed diminished reflexes and positive anti-GQ1b antibodies in cerebrospinal fluid.

Findings:

  • The patient was diagnosed with Bickerstaff's brainstem encephalitis (BBE), a rare neurological disorder.
  • Treatment with plasmapheresis led to symptom improvement and discharge within one month.

Implications:

  • Bickerstaff's brainstem encephalitis (BBE) should be considered in the differential diagnosis for ulcerative colitis patients experiencing consciousness disturbances.
  • Early recognition and treatment of BBE are crucial for favorable outcomes in susceptible populations.