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Updated: May 18, 2026

Real-time Breath Analysis by Using Secondary Nanoelectrospray Ionization Coupled to High Resolution Mass Spectrometry
Published on: March 9, 2018
Enhanced nebulization efficiency of electrospray mass spectrometry: improved sensitivity and detection limit
Anneli Kruve1, Ivo Leito, Koit Herodes
1Institute of Chemistry, University of Tartu, Tartu, 50411, Estonia. anneli.kruve@ut.ee
Abstract:
A novel electrospray nebulizer has been designed, which includes an additional nebulization gas capillary inside the liquid capillary. This design offers significantly enhanced ionization efficiency compared with the classic nebulizer design and leads to improved sensitivity (by three to 10 times) and decreases the detection limit, on an average 10 times. We see these results as the first step in the design of ESI nebulizers offering improved sensitivity and higher robustness. Possible future developments would include optimization of the dimensions of the capillaries as well as testing the nebulizer for other matrices and analytes.
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