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Updated: Jun 11, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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Published on: January 19, 2016

Photoredox-Catalyzed Radical Dideuterofluoromethylation Using a Cyclic Sulfoximine Scaffold

Gabriel Goujon1, Ivo Leito2, Märt Lõkov2

  • 1Université Paris-Saclay, UVSQ, CNRS, UMR 8180, Institut Lavoisier de Versailles, 78035 Versailles Cedex, France.

Organic Letters
|June 9, 2026
PubMed
Summary

Researchers developed novel reagents for incorporating non-PFAS fluorinated motifs like CD2F and CF2D, crucial for medicinal chemistry. This work provides new tools for drug discovery, avoiding controversial per- and polyfluoroalkyl substances (PFAS).

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